WebAlthough we found that the depletion of Fto did not affect preimplantation development, Wei et al. recently revealed that Fto mediates m 6 A demethylation of long-interspersed element-1 (LINE1 ... WebJul 22, 2024 · FTO mediates substantial m 6 A demethylation (around 7% of demethylation in poly(A) RNA and around 35% decrease of m 6 A in non-ribosomal nuclear RNA) in plant RNA, inducing chromatin openness and ...
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WebAlthough we found that the depletion of Fto did not affect preimplantation development, Wei et al. recently revealed that Fto mediates m 6 A demethylation of long-interspersed element-1 (LINE1 ... WebFeb 1, 2024 · Analogous to modified cas9 guides for DNA, the dCas13b-FTO fusion protein can achieve site-specific RNA demethylation when deployed with a guide RNA [21]. Using this approach, Liu et al. demonstrated a specific decrease in m 6 A levels at LINE1 RNAs as well as enhanced chromatin accessibility, carRNA abundance, and downstream …
WebScience AAAS WebHere, we show that FTO mediates m6A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA abundance and the local chromatin state, which in turn modulates the transcription of LINE1-containing genes. FTO-mediated LINE1 RNA m6A demethylation also plays regulatory roles in …
WebMay 11, 2024 · Fto Mediates LINE1 m 6 A Demethylation and Chromatin Regulation in mESCs and Mouse Development Scientists showed that fat mass and obesity-associated protein (FTO) mediated m 6 A demethylation of long-interspersed element-1 (LINE1) RNA in mouse ESCs, regulating LINE1 RNA abundance and the local chromatin state, which in … WebFTO mediates LINE1 m 6 A demethylation and chromatin regulation in mESCs and mouse development. Science 376 , 968–973 (2024). [17] Lulu Hu† , *, Shun Liu†, Yong Peng†, Ruiqi Ge†, Rui Su†, Chamara Senevirathne, Bryan T. Harada, Qing Dai, Jiangbo Wei, Li-Sheng Zhang, Ziyang Hao, Liangzhi Luo, Huanyu Wang, Yuru Wang, Mingkui Luo ...
WebThe minor allele T of SNP rs1861868 on FTO and minor allele A of SNP rs7975232 on VDR showed significant protective associations, [Odds ratio 0.3886 ... VDRs are abundant in adipose tissue, and it has been found that it mediates the action of vitamin D supplements to inhibit adipogenesis in 3T3-L1 preadipocyte cell line. 34 In Animal studies, ...
http://he-group.uchicago.edu/ 56里拉WebAug 4, 2024 · Here, we show that FTO mediates m6A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA abundance and the local chromatin state, which in turn modulates transcription of LINE1-containing genes. FTO-mediated LINE1 RNA m6A demethylation also plays regulatory … 56金馬獎得獎名單WebFTO gene. Fat mass and obesity-associated protein also known as alpha-ketoglutarate-dependent dioxygenase FTO is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first mRNA demethylase that has been identified. [5] 56金鐘獎WebFTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. J Wei†, X Yu†, L Yang†, X Liu†, B Gao, B Huang, X Dou, J Liu, Z Zou, ... Science 376 (6596), 968-973, 2024. 27: 2024: ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. 56銀Web8 FTO mediates LINE1 m(6)A demethylation and chromatin regulation in mESCs and mouse development. 来源：SCIENCE( P 0036-8075 E 1095-9203 ) 发表时间: 2024/05. 56週後WebMay 5, 2024 · Here, we show that FTO mediates m ⁶ A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells (mESCs), regulating LINE1 RNA abundance and the local chromatin … 56階WebMay 5, 2024 · It is shown that FTO mediates m6A demethylation of long-interspersed element-1 (LINE1) RNA in mouse embryonic stem cells, regulating LINE1 RNA abundance and the local chromatin state, which in turn modulates the transcription of LINE1-containing genes. N6-methyladenosine (m6A) is the most abundant internal modification on … 56集