Web22 dec. 2024 · Other target mechanisms such as autophagosome maturation, and autophagy-lysosomal pathway, may initiate a faulty autophagy process resulting in senile plaques due to defective lysosomal acidification and alteration in lysosomal pH. Hence, the strong link between mTOR and autophagy can be explored further as a potential … Web3 dec. 2024 · A mouse model of impaired lysosomal acidification shows iron deficiency, activation of the pseudo-hypoxia response, and pervasive inflammation, all detectable …
mTORC2 Activity Disrupts Lysosome Acidification in Systemic …
Web3 dec. 2024 · Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. Web14 sept. 2024 · There is increasing evidence that lysosomal acidification affects the activity of various hydrolases within the lysosome, as well as various additional signal functions of the lysosome, especially the regulation of nutrient sensing and nutrient homeostasis [26,54]. The proper coordinated function of multiple ion channels is involved … improve my physical health
Frontiers NLRP3 and mTOR Reciprocally Regulate Macrophage ...
Web25 apr. 2011 · Lysosomal efflux transporters are a family of lysosomal membrane proteins required for the export of lysosomal degradation products, such as amino acids and … Web25 dec. 2015 · Because mTOR pathway has been reported to be up-regulated in hepatocellular carcinoma (HCC), we used human liver cancer cell lines, HepG2 and HuH6, and a SV40-transformed human fibroblast cell line, LM217, as a control cell line [14], [15]. In the present study, in contrast to decreased mTORC1 activity under starvation conditions … WebTo examine this apparent conundrum, we investigated the effects of lysosome inhibition on mTORC1 activity; chloroquine (CQ) and Bafilomycin A1, two lysosomal acidification inhibitors, were used for pharmacological inhibition at nontoxic doses (fig. S1C); TFEB silencing was used as a genetic intervention. lithium 300mg er