Myh6 cre mouse

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August undefined, 2024

Web21 mei 2024 · Adult cardiomyocytes from the ventricles of Myh6-Cre GSDMD +/+ mice (controls) or GSDMD-CKO (cardiomyocyte-specific GSDMD-deficient) male mice were isolated, and ( A) H/R for 0.5/24 h induced the pyroptotic morphological manifestations of prominent bubble-like formations, as well as propidium iodide (PI)-positive staining of … Web7 jul. 2024 · Adult cardiomyocytes from the ventricles of Myh6-Cre GSDMD +/+ mice (controls) or GSDMD-CKO (cardiomyocyte-specific GSDMD-deficient) male mice were …

Cells Free Full-Text Depletion of VGLL4 Causes Perinatal …

Web23 jul. 2015 · Abstract. A mouse model that mediates temporal, specific, and efficient myocardial deletion with Cre-LoxP technology will be a valuable tool to determine the … Web27 jan. 2024 · Numerous pharmacotherapies, implantable devices, and surgical techniques have been pioneered over the last five decades to salvage the myocardium and prevent pathological remodeling, dramatically improving patient outcomes and quality of life following the development of HF ( Benjamin et al., 2024; Jones et al., 2024 ). children\u0027s hands on museum freeport il

005657 - αMHC-MerCreMer Strain Details

Web011038 B6.FVB-Tg(Myh6-cre)2182Mds/J The cardiac-specific alpha myosin-heavy chain ( Myh6 ) promoter drives expression of cre in this transgenic strain. The promoter induces … WebA1cf Tg(Myh6-cre/Esr1*)1Jmk: Name: APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin: MGI ID: MGI:3050453: Synonyms: alphaMHC-Cre-Mer … WebThe WT, Myh6-Cre, and Mb21d1 −/− mice had normal survival, but, as reported previously, the Myh6-Cre:Lmna F/F mice exhibit total mortality within the first 4 weeks of life with maximum and median survival rates of 25 and 20 days, respectively . 17 Deletion of the Mb21d1 gene prolonged the maximum and median survival rates of the Myh6-Cre:Lmna … gov sats year 2

Tg(Myh6-cre/Esr1*)1Liao Transgene Detail MGI Mouse …

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WebMice were received standard chow and water, and maintained on an alternating 12-h light-dark cycle. Stim1 flox/flox (Stim1 f/f; B6 (Cg)-Stim1 tm1Rao /J; stock no. 023350) mice and MHC-cre mice (B6.FVB-Tg(Myh6-cre) 2182Mds … Web24 mrt. 2024 · Toll-like receptor 4 (TLR4) is an integral factor in the initiation of the innate immune response and plays an important role in cardiovascular diseases such as hypertension and m children\u0027s handwritingWebThese results suggest that the new Myh6-Cre mouse line can serve as a robust tool to dissect the distinct roles of genes involved in heart development and function. [5] Here, we employed a cell-type-specific, cre-dependent, modified virus vector to retrogradely and anterogradely trace VN glutamatergic neurons in the VGLUT2-IRES-Cre mouse line. [6] children\u0027s hands on museum alabama

"Web21 mrt. 2024 · Myh6-driven Cre recombinase activates the DNA damage response and the cell cycle in the myocardium in the absence of loxP sites. A New Mouse Model of … " - Myh6 cre mouse

Myh6 cre mouse

Generation and characterization of a Myh6-driven Cre knockin …

WebMyh6-creERT2小鼠是什么？. 什么是cre鼠？. cre鼠就是我们常用的带有不同的cre酶的工具鼠统称，可用于繁育交配，比如说B6.129P2-Lyz2 tm1 (cre)lfo/NJU, 这种就是我们的带有骨髓细胞特异表达cre酶的模型，还有很多很多在不同组织表达的酶的模型，可以根据自己的实 … WebMachine learning reveals STAT motifs as predictors for GR-mediated gene repression.

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Web1 feb. 2024 · Myh6-Cre transgenic mouse line was known to express Cre recombinase only in the heart. Nevertheless, during breeding Myh6-Cre to Rosa26 fstdTom reporter … Web1 jul. 2024 · Second, we observed Cre-associated toxicity, with lower body weights and increased global fibrosis, in Cre-only control male mice compared with flox-only controls, …

WebAbstract. Discovering determinants of cardiomyocyte maturity and the maintenance of differentiated states is critical to both understanding development and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic strategy. WebTg (Myh6-cre/Esr1*)1Liao. Mutation details : This transgene expresses a cre recombinase/ mutant estrogen receptor ligand-binding domain fusion protein under the control of a …

Web5 mrt. 2024 · Myh6-MerCreMer:LARP7 f/f mice were injected with 25 mg/kg/d tamoxifen (iCKO) for continuous 5 days at 2 months of age to deplete LARP7 from cardiomyocytes. Two-month-old MerCreMer mice with the same tamoxifen injection plan were used as controls (n=6 to 7; 2-tailed Student t test; ** P <0.01). WebTo test this hypothesis, cardiomyocyte-specific TLR4 knockdown (cTLR4KO) mice were generated by crossing floxed TLR4 mice with Myh6-Cre mice, and subjected to angiotensin II (Ang II, 1 µg/kg/min or vehicle for 14 days) hypertension model.

Web18 okt. 2024 · 而Cre-loxP位点特异性重组系统（简称Cre-loxP重组系统）的建立，为完善基因编辑小鼠模型的构建，进一步开展条件性靶基因功能的研究，提供了有效工具。. 回顾Cre-loxP重组系统在小鼠研究中的实际应用，研究者们认识到，对该技术应用中存在的某些风险与 …

Web14 mei 2024 · Here, we develop Myh6-Cre double KO (DKO) ( Mbnl1−/−; Mbnl2cond/cond; Myh6-Cre+/−) mice to eliminate Mbnl1/2 in cardiomyocytes and observe spontaneous lethal cardiac events under no anesthesia. RNA sequencing recapitulates DM heart spliceopathy and shows gene expression changes that were previously undescribed in DM heart studies. children\u0027s hands-on museumWeb009074 STOCK Tg(Myh6-cre)1Jmk/J These transgenic mice express nuclear-localizing Cre recombinase under the control of the mouse Myh6 (myosin, heavy polypeptide 6, … children\u0027s hands on museum in tuscaloosaWeb2 jun. 2024 · The Myh6-Cre Lmna F/F mice showed increased mortality, notably starting at 3 weeks of age and rapidly progressing to 100% mortality by 4 weeks . The Myh6-Cre Lmna W/F mice also exhibited an increased mortality albeit at an older age, reaching 100% mortality by 15 months of age (Figure 1F and inset). children\\u0027s hands-on museumWeb7 mrt. 2024 · We next characterized the hearts of adult Myh6-Cre;Thra DN /+ mutant mice and their regenerative capacity . Adult thyroid hormone mutant hearts were 37% larger than controls ( Fig. 4B and fig. S16) and contained an increased number (approximately twofold) of cardiomyocytes as shown with both dissociation ( Fig. 4C ) and stereological methods … gov. ruth ann minnerWeb20 sep. 2024 · The Myh6-Cre mouse line was generated by the Shanghai Model Organisms Center, INC. This newly generated mouse line is available from the … gov savings allowanceWebFigure 1. Cardiac arrhythmias in Taz cardiac-specific knockout mice. Male control (TazFL/Y) or cardiac-specific mutant mice (CKO, Myh6-Cre; TazFL/Y) underwent intracardiac electrophysiology study at 6 weeks of age. Studies and analyses were performed blinded to genotype. A, Schematic of electrophysiology study protocol. B, Fraction of mice with … gov savings bonds calculatorWebFor example, β2-adrenoceptor agonists have been indicated in regulating skeletal muscle mass. 29 In addition, GPR56, a transcriptional target of peroxisome proliferator-activated receptor gamma coactivator 1-alpha 4 (PGC-1α4), is also involved in muscle hypertrophy. 30 Moreover, β2-adrenergic receptors and GPR56 are both reported to initiate … children\u0027s hands on museum olympia