Read across approach toxicology

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August undefined, 2024

WebNov 28, 2024 · Read-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental … WebRead-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to "similar" (target) compound (s).

Read-Across to Fill Toxicological Data Gaps - ScienceDirect

WebJul 12, 2013 · The Chemical–Biological Read-Across (CBRA) approach infers each compound’s toxicity from both chemical and biological analogues whose similarities are … WebRead-across is one approach frequently used in the risk assessment of substances that lack information on their physical-chemical or toxicological properties, or their environmental … billy smart\\u0027s circus

Internationalization of read-across as a validated new …

WebSociety of Toxicology (SOT) WebComputational Toxicology 3 Definitions: Read-across • Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. • A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. • WebJul 8, 2024 · Inspired by the increasingly used read-across approach, we created a new type of QSAR, which is based on similarity of chemicals and not on chemical descriptors. A landscape of the chemical universe using 10 million structures was calculated, when based on Tanimoto indices similar chemicals are close and dissimilar chemicals far from each … billy smarts circus poster

Read-Across Methodology in Toxicological Risk …

Bibra Read-Across

Web• Computational toxicologist expert in in silico chemical safety assessment • Professional expertise in generating (eco)toxicological and physicochemical data by means of in silico approaches (QSAR, expert systems and read-across) in compliance with the current regulations (e.g., REACH, CLP, ICH M7 guideline, Biocides and Cosmetics … WebJun 23, 2024 · The concept of chemical similarity has many applications in several fields of cheminformatics. One common use of chemical similarity measurements, based on the principle that similar molecules have similar properties, is in the context of the read-across approach, where estimates of a specific endpoint for a chemical are obtained starting … billy smart junior childrenWebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has been used in a relatively specialist context implying “accepted” structural similarity, particularly within well-defined chemical classes. cynthia davies

"Weband read across approach. Case Studies – Examples of NAMs Prediction of a 90 day Repeated Dose Toxicity Study . for 2-Ethylbuturic acid using a . read-across approach to other branched carboxylic acids. ... (NAM) for regulatory toxicology. ALTEX. 2024 Apr 30. doi: 10.14573/altex.1912181. " - Read across approach toxicology

Read across approach toxicology

Integrative Chemical–Biological Read-Across Approach for …

WebMar 27, 2024 · We developed Generalized Read-Across (GenRA) ( Shah et al., 2016) for automated read-across prediction of a property of a chemical (called the target) as a similarity weighted average of the same property from analogues (also referred to as source analogues) ( Low et al., 2013 ). WebJan 1, 2024 · These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety …

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WebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ... WebJun 19, 2024 · Read-Across Methodology in Toxicological Risk Assessment Introduction. Chemical risk assessment aims at compound-specific threshold values, like acceptable …

WebDec 1, 2024 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods Regulatory Toxicology and Pharmacology, Volume 137, 2024, Article 105293 Show abstract Research article Nitrocellulose blister material as a source of N-nitrosamine contamination of … WebDec 21, 2024 · The Strategic Plan has three core components: (1) identifying, developing and integrating NAMs for TSCA decisions; (2) building confidence that the NAMs are scientifically reliable and relevant for TSCA decisions; and (3) implementing the reliable and relevant NAMs for TSCA decisions. On this page: Implementing the Strategic Plan

WebComputational Toxicology Generalised Read-Across GenRA, research, implementation and practical application. ToxPi. PRIORITIZATION. Interactive Chemica Sl afety for Sustainability Web Application TOXCAST iCSS v0.5 Tool Tip Description of Assays (Data) or . Prioritization Mode whatever is being hovered over Desc Summary Log 80-05-7 80-05-1 80-05 ... WebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ...

WebApr 30, 2024 · defines grouping of substances and read-across approach as: “ Substances whose physicochemical, toxicological and ecotoxicological properties are likely to be …

WebComputational Toxicology. Background & definitions • Read-across describes one of the data gap filling techniques used within analogue and category approaches • “Analogue approach” refers to grouping based on a very limited number of chemicals (e.g. target substance) + source substance) • “Category approach” is used when grouping ... cynthia davies night courtWeb1 day ago · Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury … cynthia davis 60WebCategory formation, grouping and read across methods are broadly applicable in toxicological assessments and may be used to fill data gaps for chemical safety … cynthia davis bame recruitmentWebGrouping of substances and read-across is one of the most commonly used alternative approaches for filling data gaps in registrations submitted under REACH. This approach … cynthia daveyWebNov 12, 2024 · The aim of regulatory toxicology is to prevent hazardous substances and products from producing adverse effects on human health and on the environment. 100 In … billy smalls jamaicaWebRead-across describes one of the techniques for filling data gaps in either the analogue or category approaches i.e. not to be confused with the “analogue approach” – “Analogue … billy smart circusWebread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach cynthia davis artist st ives